This project provides simple nanotechnology based solutions to alter the surface characteristics of current Titanium bone implants in order to achieve smart and multifunctional implants with antiinfection, antiinflammatory, and improved osteoinegrative properties. The longterm goal is to improve the success of implants in patients who are medically compromised, elderly, smoke, or who have limited quantity or quality of bone.
At UIC-In-situ-Nanomedicine Laboratory, we are developing Multifunctional Bone Implants that are smart to not only induce bone growth but also ecognize the changes in the microenvironments around them in order to prevent or reduce surgical complications such as inflammation and infection. This multifunctionality is achieved by embedding antimicrobial nanoparticles within nanotubes and loading the tubes with ant infectious agents [Ag , and AgO] and antiinflammatory drugs [Naproxen Sodium]. The goal is to improve the state of currently wellestablished titanium implants without the need for modifying the surgical technique or changing the implant design.
The BEST Fellow will visit the ISNL lab at UIC Bioengineering Department, to observe the actual Multifunctional Bone Implant fabrication process. Dr. Shokuhfar and her PhD students will explain the concepts behind the need for such observation and the aim for using the system to synthesis nanomaterials that are important for dentistry as well as their potential application in advanced prosthodontics. The teachers will gain required training on the fabrication processes. Once they have successfully learned the biofabrication then they will fabricate such surfaces on an actual dental implant. Next they will assist with validating their surfaces using Field Emission Transmission Electron Microscopy (FESEM) and Energy Dispersive Spectroscopy (EDS). Depending on time and Fellow interest, corrosion tests and/or water contact angle (WCA) measurements on the modified dental implants can be performed.